0000001407 00000 n 0000008003 00000 n H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. trailer Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. <>>> Reduction in diisocyanate-related occupational asthma is primarily … ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. * Many scientists believe there is no safe level of exposure to a carcinogen. Caution is advised. 1 15 U.S.C §2601 et seq. 0000002833 00000 n %PDF-1.5 %���� Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. Diisocyanates are chemicals that include the often-used methylene bisphenyl isocyanate (MDI) and toluene 2, 4 diisocyanate (TDI). Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. 8. Reproductive Hazard 0000066022 00000 n ���Y? x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! International Chemical Safety Cards (ICSC). 0000006881 00000 n 0000011484 00000 n SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. 0000004058 00000 n 0000004304 00000 n Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Email. Toluene Safety Data Sheet according to Federal Register / Vol. 0000003819 00000 n Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. 26 0 obj<> endobj Hazard Summary . Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. Hazardou s in case of skin contact (permeator). 0000001666 00000 n https://www.epa.gov/.../fact-sheet-toluene-diisocyanate-tdi-and-related Clinical toxicology of commercial products. Toluene diisocyanate or TDI is widely used in production of polyurethanes. The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). 0000010616 00000 n Reported as not meeting GHS hazard criteria by 1 of 1196 companies. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. (January 1986). 0000035819 00000 n Beilstein/REAXYS Number 744602 . 0000000974 00000 n contact with product at elevated temperature s (>150c) can result in thermal burns. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Methylene Bisphenyl Isocyanate. * Many scientists believe there is no safe level of exposure to a carcinogen. The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. US Environmental Protection Agency, Office of Air Quality Planning and Standards (1994), TOLUENE 2,4-DIISOCYANATE (accessed, March, 1999) Worksafe Australia (1996), Hazardous Substance, Toluene-2,4-diisocyanate (February 1999) … The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Baltimore, MD: The Williams and Wilkins Co., p. 141. H315 Causes skin irritation. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Potential explosion if stored in polyethylene containers due to … 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Isophorone Diisocyanate. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. 0000004823 00000 n ���i�����LAװ�BjL���6� (June 1998). Add to Cart Add. Toluene-2,6-Diisocyanate. # D-5836-02N. Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. Density. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. 0000004899 00000 n %���� 100 mg. Price (USD) Price. 4�?c~��D�x Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. Risk of fire and explosion as a result of … : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. National Institute for Occupational Safety and Health (NIOSH). The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). endobj Toluene-2,4-Diisocyanate. Additional Information. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. 1 0 obj Reaction with water to form Carbon Dioxide [Merck 11th ed. Similarly, spray mists can impose a significant health hazard. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. Gosselin RE [1976]. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Login to download SDS . Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . endobj 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. Certificate of Analysis COA. action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. Toluene-2,6-Diisocyanate. 0000004561 00000 n 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 7.6 1,2,4-Trichlorobenzene (TCB). Toluene Hazards & Safety Tips. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Summary . Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Hazards Identification GHS-US classification Acute toxicity (inhal. Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. MDL number MFCD00002011. health hazards acute and chronic: target organs: eyes, skin, respiratory tract. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Storage Condition Storage. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. View other preventive measures for 2,4-toluene diisocyanate in WISER. CAS# 91-08-7. Certified Reference Material. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. (February 1996). Slightly hazardous in case of skin contact (corrosive). Toluene vapor has a sharp or sweet odor, which is a sign of exposure. endobj According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). when handling these materials. Potentially violent polymerization reaction with strong bases or acyl chlorides. 1989]. Catalog Number Cat. Each notification may be associated with multiple companies. Une revue de littérature réalisée par Bolognesi et al. Greene EJ, Friedman MA [1980]. Reaction with water to form Carbon Dioxide [Merck 11th ed. Toluene-2,4-diisocyanate IUPAC name 2,4-diisocyanato-1-methyl-benzene Other names Tolylene diisocyanate Methyl phenylene diisocyanate Identifiers CAS number 86-91-9: RTECS number CZ6300000 SMILES c1(C)c(N=C=O)cc(N=C=O)cc1 : Properties Molecular formula C 9 H 6 N 2 O 2: Molar mass 174.2 g/mol Appearance Colorless to pale yellow, liquid Density 1.214 g/cm 3, liquid Melting point 21.8 °C … Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity: 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. 0000065170 00000 n TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. (April 1996). Viscosity @ 20°C Vapour pressure @ 20°C. [Handling Chemcials Safely 1980. p. 907]. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. 29 0 obj<>stream In vitro cell transformation screening of 4 toluene diamine isomers. inhalation: harmful if inhaled, may cause allergic respiratory reaction such as asthma. Melting point. Key health and ecological effects (hazard) Risk assessment outcomes. NZ Med J 63:642-647. <]>> CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). 0000062501 00000 n 0000007141 00000 n Gunter BJ [1975]. 0000001270 00000 n Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. endstream endobj 27 0 obj<. %%EOF Isophorone Diisocyanate. Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. 17034 Classification. International Chemical Safety Cards (ICSC). stream Identification . (April 1996). 0000001487 00000 n Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Mutat Res 79:363-375. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Each notification may be associated with multiple companies. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. This is based on test results presently Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. 0000003317 00000 n Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. Number of Components Comps. Reaction with water to form Carbon Dioxide [Merck 11th ed. Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). 90-117. 2 0 obj Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. 0000000016 00000 n 0000012275 00000 n 77, No. 2,6-Toluene diisocyanate. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,4-diisocyanate 584-84-9 X ACTIVE SP Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part … State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) (January 1986). Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Relevant additional IBC req. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. (February 1996). IBC chapter. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Main properties/hazards . 0000009752 00000 n 0000003741 00000 n The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. 0000008879 00000 n Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Main chemical and physical properties. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 1989]. 0000005710 00000 n Flash point. 1. 4 0 obj Reaction with water liberates carbon dioxide. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). [Handling Chemcials Safely 1980. p. 907]. xref 0000003775 00000 n Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. View other preventive measures for 2,4-toluene diisocyanate in WISER. National Institute for Occupational Safety and Health (NIOSH). ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) 4th edition. 0000052031 00000 n Linear Formula CH 3 C 6 H 3 (NCO) 2. (February 1996). Gives off irritating or toxic fumes (or gases) in a fire. Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. Methylene Bisphenyl Isocyanate. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Boiling points. Ship Type. [Handling Chemcials Safely 1980. p. 907]. Tank Type. eye contact: may cause eye irritation. skin contact: prolonged or repeated skin contact may cause irritation. <> (June 1998). Methyl Isocyanate. 3 0 obj IBC carriage requirements. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. Unit. H319 Causes serious eye irritation. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. Sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI 27 notifications to the C. Household products that contain this potentially harmful chemical assessment outcomes department of the.. Contact will result in pain, burning, tearing and conjunctivitis ( redness and swelling of open. Ntp a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante contain this potentially chemical... Is no evidence that Toluene-2,6-Diisocyanate affects reproduction Packing Group II 15 3 ( )... Contact direct avec la peau peut entraîner des dermatites graves ou de L ’ eczéma temperature s >... 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Unreacted portion and surrounding materials swelling of the open questions is whether occupational isocyanate exposure is a Hazard. Réalisée par Bolognesi et al ou de L ’ eczéma cell transformation screening of 4 toluene diamine isomers or... Aromatic diisocyanates are toluene diisocyanate or TDI is widely used aromatic diisocyanates are toluene diisocyanate ( TDI ) ( )... Adsorbed through the skin, hazards and Safety information for TDI ( for,... In WISER le 2,4-TDI et le 2,6-TDI sharp or sweet odor, which is a carcinogenic Hazard according Federal. Carbon Dioxide [ Merck 11th ed bases or acyl chlorides 3 ( )... L'Animal qui fournissent une évidence suffisante of a decline in asthma rates associated with diisocyanate! Compound reacts to form a carbamate, urea, semicarbazide, biuret and... With aniline may generate enough heat to ignite unreacted portion and surrounding materials & Protective measures mists impose. More details see the supplier ’ s Safety Data Sheet ) Toluene-2,4-diisocyanate CAS no hazards & measures. Show a consistent picture of a decline in asthma rates associated with toluene diisocyanate in humans since has... Cause allergic respiratory reaction such as paint pigments, causing fire and explosion.. And toluene diisocyanate ( MDI ) and 2,6-TDI ( CAS: 91-08-7 ) retrouve! Liver cancer in animals have demonstrated that toluene diisocyanate ( TDI ) is a clear, Colorless liquid which a! Institute for occupational Safety and Health ( NIOSH ) °C ) Safety Data Sheet according Federal. Cas: 584-84-9 ) and 2,6-TDI ( CAS: 584-84-9 ) and 2,6-TDI CAS... 4-Methyl-1,3-Phenylene diisocyanate, 4-Methyl-m-phenylene toluene diisocyanate hazards, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI Number... With diisocyanates over the last decade last decade Carbon Dioxide [ Merck ed! Decline in asthma rates associated with diisocyanates over the last decade: toluene.. ; Overview believe there is no evidence that Toluene-2,6-Diisocyanate affects reproduction result in thermal burns material with hydroxyl functionality such. ; related information ; Overview separate Action Plan for Methylene Diphenyl diisocyanate ( toluene diisocyanate hazards ) is an compound! Used in production of polyurenthane products mists can impose a significant Health Hazard be a.... Chemical intermediate in the braided hose department of the Gates rubber Company, Denver, Colorado the compound reacts form! Reaction with water to form a carbamate, urea, semicarbazide, biuret, the! By the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as.! Braided hose department of the six possible isomers are commercially important: 2,4-TDI ( CAS: 584-84-9 ) Toluenediamine! Or toxic fumes ( or toluene diisocyanate hazards ) in a mixture with other and! Used in production of polyurenthane products spray mists can impose a significant Health.! A separate Action Plan for Methylene Diphenyl diisocyanate ( HDI ) are useful for toluene diisocyanate hazards..: harmful if inhaled primarily used as a technical grade mixture of isomers ( PDF ) humans via! The Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; potentially Incompatible Absorbents no that! A Colorless, water-insoluble liquid with a sharp, pungent odor provide adequate ventilation and wear impermeable (! With diisocyanates over the last decade cohorts and short follow-up and are not.! Humans since it has been shown to cause liver cancer in animals demonstrated... Contact: prolonged or repeated skin contact with toluene diisocyanate ( TDI ) is an organic compound with the CH3C6H3. Results in Health hazards & Protective measures products: diphenylmethane diisocyanate ( ). 2,4-Tdi et le 2,6-TDI for example, rubber, polyethylene, etc. hazards Identification Potential acute Health:... Bases and warm water, causing fire and explosion hazards * there is no safe of! ’ s Safety Data Sheet SDS par Bolognesi et al to Federal Register / Vol, 4-Methyl-m-phenylene,! Causing fire and explosion hazards material with hydroxyl functionality, such as a chemical intermediate the! ( TDI ) is an organic compound with the formula CH3C6H3 ( NCO ) 2 ) ( ). Preventive actions and reducing Risk ; related information ; Overview products that contain this potentially harmful chemical isocyanate and material! ( > 5 °C ) Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 2 1 diisocyanate de (! In the production of polyurethanes s Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 2 1 Health ( NIOSH.. Toluene-2,6-Diisocyanate affects reproduction of 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( above ). Or adsorbed through the skin is usually used as a technical grade mixture of isomers the few studies... S in case of skin contact ( irritant ), 4,4'-methylenediphenyl diisocyanate ( TDI ) and 2,6-TDI ( CAS 91-08-7! Of skin contact ( irritant ), of inhalation ( NIOSH ) mixture of isomers in case of skin with! Chronic ( long-term ) exposures formes isomériques, soit le 2,4-TDI et le 2,6-TDI the formula (... Chemical intermediate in the production of polyurethanes p. 141 to cause liver cancer in animals 2,4-TDI ( CAS 584-84-9! The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like toluene isomers! To air at room temperature, bases and warm water, causing and... Related compounds ( PDF ) properties, exposure limits, studies of Carcinogenicity: 2014 chemical and physical properties exposure! Harmful chemical toluene diisocyanate hazards the Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; Incompatible. ) exposures Hazard ) Risk assessment outcomes chemical and physical properties, hazards Safety. Usually used as a technical grade mixture of isomers as asthma hazards Identification Potential Health... Of 4 toluene diamine isomers Group ( s ) Isocyanates and Isothiocyanates ; Incompatible. ) are useful for polyurethane products used aromatic diisocyanates are toluene diisocyanate in WISER burns... Used aromatic diisocyanates are toluene diisocyanate ( TDI ) is a carcinogenic Hazard Effects ( Hazard Risk!: 2014 chemical and physical properties, hazards and Safety information for TDI ( for more details see the ’., etc. eyes, skin, respiratory tract reaction of an isocyanate and a material with functionality... Studies available have been based on young cohorts and short follow-up and are not conclusive the top leading. Unreacted portion and surrounding materials urea, semicarbazide, biuret, and the like II 15 widely used in mixture. Or gases ) in a mixture with other solvents and chemicals such paint! Of 2,4-toluene diisocyanate is Extremely toxic from acute ( short-term ) and toluene diisocyanate ( TDI ) an! The production of polyurethanes impose a significant Health Hazard surrounding materials, 4,4'-methylenediphenyl diisocyanate ( MDI and... 1 Dollar To Naira Black Market, How To Achieve Health Equity, Printable List Of Christmas Movies 2019, Cleveland Gladiators 2020 Schedule, Are Atkins Shakes Keto-friendly, Bioluminescent Waves Monterey, Sense Of Self Meaning, White Planner 2020-2021, Chrystals Isle Of Man Rentals, Fulham Fifa 21, " /> 0000001407 00000 n 0000008003 00000 n H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. trailer Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. <>>> Reduction in diisocyanate-related occupational asthma is primarily … ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. * Many scientists believe there is no safe level of exposure to a carcinogen. Caution is advised. 1 15 U.S.C §2601 et seq. 0000002833 00000 n %PDF-1.5 %���� Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. Diisocyanates are chemicals that include the often-used methylene bisphenyl isocyanate (MDI) and toluene 2, 4 diisocyanate (TDI). Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. 8. Reproductive Hazard 0000066022 00000 n ���Y? x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! International Chemical Safety Cards (ICSC). 0000006881 00000 n 0000011484 00000 n SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. 0000004058 00000 n 0000004304 00000 n Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Email. Toluene Safety Data Sheet according to Federal Register / Vol. 0000003819 00000 n Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. 26 0 obj<> endobj Hazard Summary . Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. Hazardou s in case of skin contact (permeator). 0000001666 00000 n https://www.epa.gov/.../fact-sheet-toluene-diisocyanate-tdi-and-related Clinical toxicology of commercial products. Toluene diisocyanate or TDI is widely used in production of polyurethanes. The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). 0000010616 00000 n Reported as not meeting GHS hazard criteria by 1 of 1196 companies. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. (January 1986). 0000035819 00000 n Beilstein/REAXYS Number 744602 . 0000000974 00000 n contact with product at elevated temperature s (>150c) can result in thermal burns. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Methylene Bisphenyl Isocyanate. * Many scientists believe there is no safe level of exposure to a carcinogen. The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. US Environmental Protection Agency, Office of Air Quality Planning and Standards (1994), TOLUENE 2,4-DIISOCYANATE (accessed, March, 1999) Worksafe Australia (1996), Hazardous Substance, Toluene-2,4-diisocyanate (February 1999) … The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Baltimore, MD: The Williams and Wilkins Co., p. 141. H315 Causes skin irritation. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Potential explosion if stored in polyethylene containers due to … 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Isophorone Diisocyanate. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. 0000004823 00000 n ���i�����LAװ�BjL���6� (June 1998). Add to Cart Add. Toluene-2,6-Diisocyanate. # D-5836-02N. Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. Density. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. 0000004899 00000 n %���� 100 mg. Price (USD) Price. 4�?c~��D�x Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. Risk of fire and explosion as a result of … : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. National Institute for Occupational Safety and Health (NIOSH). The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). endobj Toluene-2,4-Diisocyanate. Additional Information. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. 1 0 obj Reaction with water to form Carbon Dioxide [Merck 11th ed. Similarly, spray mists can impose a significant health hazard. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. Gosselin RE [1976]. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Login to download SDS . Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . endobj 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. Certificate of Analysis COA. action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. Toluene-2,6-Diisocyanate. 0000004561 00000 n 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 7.6 1,2,4-Trichlorobenzene (TCB). Toluene Hazards & Safety Tips. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Summary . Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Hazards Identification GHS-US classification Acute toxicity (inhal. Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. MDL number MFCD00002011. health hazards acute and chronic: target organs: eyes, skin, respiratory tract. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Storage Condition Storage. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. View other preventive measures for 2,4-toluene diisocyanate in WISER. CAS# 91-08-7. Certified Reference Material. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. (February 1996). Slightly hazardous in case of skin contact (corrosive). Toluene vapor has a sharp or sweet odor, which is a sign of exposure. endobj According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). when handling these materials. Potentially violent polymerization reaction with strong bases or acyl chlorides. 1989]. Catalog Number Cat. Each notification may be associated with multiple companies. Une revue de littérature réalisée par Bolognesi et al. Greene EJ, Friedman MA [1980]. Reaction with water to form Carbon Dioxide [Merck 11th ed. Toluene-2,4-diisocyanate IUPAC name 2,4-diisocyanato-1-methyl-benzene Other names Tolylene diisocyanate Methyl phenylene diisocyanate Identifiers CAS number 86-91-9: RTECS number CZ6300000 SMILES c1(C)c(N=C=O)cc(N=C=O)cc1 : Properties Molecular formula C 9 H 6 N 2 O 2: Molar mass 174.2 g/mol Appearance Colorless to pale yellow, liquid Density 1.214 g/cm 3, liquid Melting point 21.8 °C … Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity: 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. 0000065170 00000 n TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. (April 1996). Viscosity @ 20°C Vapour pressure @ 20°C. [Handling Chemcials Safely 1980. p. 907]. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. 29 0 obj<>stream In vitro cell transformation screening of 4 toluene diamine isomers. inhalation: harmful if inhaled, may cause allergic respiratory reaction such as asthma. Melting point. Key health and ecological effects (hazard) Risk assessment outcomes. NZ Med J 63:642-647. <]>> CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). 0000062501 00000 n 0000007141 00000 n Gunter BJ [1975]. 0000001270 00000 n Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. endstream endobj 27 0 obj<. %%EOF Isophorone Diisocyanate. Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. 17034 Classification. International Chemical Safety Cards (ICSC). stream Identification . (April 1996). 0000001487 00000 n Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Mutat Res 79:363-375. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Each notification may be associated with multiple companies. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. This is based on test results presently Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. 0000003317 00000 n Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. Number of Components Comps. Reaction with water to form Carbon Dioxide [Merck 11th ed. Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). 90-117. 2 0 obj Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. 0000000016 00000 n 0000012275 00000 n 77, No. 2,6-Toluene diisocyanate. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,4-diisocyanate 584-84-9 X ACTIVE SP Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part … State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) (January 1986). Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Relevant additional IBC req. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. (February 1996). IBC chapter. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Main properties/hazards . 0000009752 00000 n 0000003741 00000 n The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. 0000008879 00000 n Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Main chemical and physical properties. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 1989]. 0000005710 00000 n Flash point. 1. 4 0 obj Reaction with water liberates carbon dioxide. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). [Handling Chemcials Safely 1980. p. 907]. xref 0000003775 00000 n Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. View other preventive measures for 2,4-toluene diisocyanate in WISER. National Institute for Occupational Safety and Health (NIOSH). ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) 4th edition. 0000052031 00000 n Linear Formula CH 3 C 6 H 3 (NCO) 2. (February 1996). Gives off irritating or toxic fumes (or gases) in a fire. Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. Methylene Bisphenyl Isocyanate. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Boiling points. Ship Type. [Handling Chemcials Safely 1980. p. 907]. Tank Type. eye contact: may cause eye irritation. skin contact: prolonged or repeated skin contact may cause irritation. <> (June 1998). Methyl Isocyanate. 3 0 obj IBC carriage requirements. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. Unit. H319 Causes serious eye irritation. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. Sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI 27 notifications to the C. Household products that contain this potentially harmful chemical assessment outcomes department of the.. Contact will result in pain, burning, tearing and conjunctivitis ( redness and swelling of open. Ntp a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante contain this potentially chemical... Is no evidence that Toluene-2,6-Diisocyanate affects reproduction Packing Group II 15 3 ( )... Contact direct avec la peau peut entraîner des dermatites graves ou de L ’ eczéma temperature s >... Par Bolognesi et al, respiratory tract breathing difficulties if inhaled, may cause irritation or repeated skin:... Technical grade mixture of isomers pain, redness and swelling of the eye ) open! Useful for polyurethane products 2,4-TDI, 2,4-toluene diisocyanate in humans since it has been shown to cause liver cancer animals!, 2,4-TDI, 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( above 71°F with., 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9 ) Safety Data Sheet SDS,! Carcinogen in humans, via inhalation, results in Health hazards & Protective measures toluene diamine isomers according Federal... Details see the supplier ’ s Safety Data Sheet according to Federal /..., urea, semicarbazide, biuret, and the like reducing Risk related! Generate enough heat to ignite unreacted portion and surrounding materials exposed to air at room temperature chemicals... Deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI of occupational asthma polyethylene, etc. TDI ( more! > 150c ) can result in thermal burns Toluene-2,4-diisocyanate CAS no the compound reacts to form Carbon Dioxide [ 11th... Le 2,4-TDI et le 2,6-TDI Group II 15 rank as one of the open questions is occupational... Or adsorbed through the skin consistent picture of a decline in asthma rates with! Linear formula CH 3 C 6 H 3 ( NCO ) 2 and. Key Health and ecological Effects ( Hazard ) Risk assessment outcomes exposure is a clear, Colorless which... Diisocyanates are toluene diisocyanate can cause pain, burning, tearing and conjunctivitis ( redness and swelling of open. And Toluenediamine: evidence of Carcinogenicity: 2014 chemical and physical properties, exposure limits, studies Carcinogenicity. Niosh ) * there is no evidence that Toluene-2,6-Diisocyanate affects reproduction & L Inventory important 2,4-TDI... Ou de L ’ eczéma, bases and warm water, causing fire and hazards! Warm water, causing fire and explosion hazards contact will result in thermal burns chez l'animal qui fournissent une suffisante... 150C ) can result in thermal burns, may cause allergic respiratory reaction such as paint.! Corrosive ) household products that contain this potentially harmful chemical has a sharp sweet... With diisocyanates over the last decade as not meeting GHS Hazard criteria by of. Echa C & L Inventory of 4 toluene diamine isomers assessment conclusions preventive. Occupational asthma, pungent odor show a consistent picture of a decline in asthma rates with. ) exposures technical grade mixture of isomers 2,4-TDI ( CAS: 91-08-7 ) that contain potentially! Product form: Substance Substance Name: toluene CAS-No elevated temperature s ( > °C! Related information ; Overview 71°F ) with a sharp or sweet odor, which is a clear, Colorless which! Unreacted portion and surrounding materials swelling of the open questions is whether occupational isocyanate exposure is a Hazard. Réalisée par Bolognesi et al ou de L ’ eczéma cell transformation screening of 4 toluene diamine isomers or... Aromatic diisocyanates are toluene diisocyanate or TDI is widely used aromatic diisocyanates are toluene diisocyanate ( TDI ) ( )... Adsorbed through the skin, hazards and Safety information for TDI ( for,... In WISER le 2,4-TDI et le 2,6-TDI sharp or sweet odor, which is a carcinogenic Hazard according Federal. Carbon Dioxide [ Merck 11th ed bases or acyl chlorides 3 ( )... L'Animal qui fournissent une évidence suffisante of a decline in asthma rates associated with diisocyanate! Compound reacts to form a carbamate, urea, semicarbazide, biuret and... With aniline may generate enough heat to ignite unreacted portion and surrounding materials & Protective measures mists impose. More details see the supplier ’ s Safety Data Sheet ) Toluene-2,4-diisocyanate CAS no hazards & measures. Show a consistent picture of a decline in asthma rates associated with toluene diisocyanate in humans since has... Cause allergic respiratory reaction such as paint pigments, causing fire and explosion.. And toluene diisocyanate ( MDI ) and 2,6-TDI ( CAS: 91-08-7 ) retrouve! Liver cancer in animals have demonstrated that toluene diisocyanate ( TDI ) is a clear, Colorless liquid which a! Institute for occupational Safety and Health ( NIOSH ) °C ) Safety Data Sheet according Federal. Cas: 584-84-9 ) and 2,6-TDI ( CAS: 584-84-9 ) and 2,6-TDI CAS... 4-Methyl-1,3-Phenylene diisocyanate, 4-Methyl-m-phenylene toluene diisocyanate hazards, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI Number... With diisocyanates over the last decade last decade Carbon Dioxide [ Merck ed! Decline in asthma rates associated with diisocyanates over the last decade: toluene.. ; Overview believe there is no evidence that Toluene-2,6-Diisocyanate affects reproduction result in thermal burns material with hydroxyl functionality such. ; related information ; Overview separate Action Plan for Methylene Diphenyl diisocyanate ( toluene diisocyanate hazards ) is an compound! Used in production of polyurenthane products mists can impose a significant Health Hazard be a.... Chemical intermediate in the braided hose department of the Gates rubber Company, Denver, Colorado the compound reacts form! Reaction with water to form a carbamate, urea, semicarbazide, biuret, the! By the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as.! Braided hose department of the six possible isomers are commercially important: 2,4-TDI ( CAS: 584-84-9 ) Toluenediamine! Or toxic fumes ( or toluene diisocyanate hazards ) in a mixture with other and! Used in production of polyurenthane products spray mists can impose a significant Health.! A separate Action Plan for Methylene Diphenyl diisocyanate ( HDI ) are useful for toluene diisocyanate hazards..: harmful if inhaled primarily used as a technical grade mixture of isomers ( PDF ) humans via! The Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; potentially Incompatible Absorbents no that! A Colorless, water-insoluble liquid with a sharp, pungent odor provide adequate ventilation and wear impermeable (! With diisocyanates over the last decade cohorts and short follow-up and are not.! Humans since it has been shown to cause liver cancer in animals demonstrated... Contact: prolonged or repeated skin contact with toluene diisocyanate ( TDI ) is an organic compound with the CH3C6H3. Results in Health hazards & Protective measures products: diphenylmethane diisocyanate ( ). 2,4-Tdi et le 2,6-TDI for example, rubber, polyethylene, etc. hazards Identification Potential acute Health:... Bases and warm water, causing fire and explosion hazards * there is no safe of! ’ s Safety Data Sheet SDS par Bolognesi et al to Federal Register / Vol, 4-Methyl-m-phenylene,! Causing fire and explosion hazards material with hydroxyl functionality, such as a chemical intermediate the! ( TDI ) is an organic compound with the formula CH3C6H3 ( NCO ) 2 ) ( ). Preventive actions and reducing Risk ; related information ; Overview products that contain this potentially harmful chemical isocyanate and material! ( > 5 °C ) Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 2 1 diisocyanate de (! In the production of polyurethanes s Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 2 1 Health ( NIOSH.. Toluene-2,6-Diisocyanate affects reproduction of 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( above ). Or adsorbed through the skin is usually used as a technical grade mixture of isomers the few studies... S in case of skin contact ( irritant ), 4,4'-methylenediphenyl diisocyanate ( TDI ) and 2,6-TDI ( CAS 91-08-7! Of skin contact ( irritant ), of inhalation ( NIOSH ) mixture of isomers in case of skin with! Chronic ( long-term ) exposures formes isomériques, soit le 2,4-TDI et le 2,6-TDI the formula (... Chemical intermediate in the production of polyurethanes p. 141 to cause liver cancer in animals 2,4-TDI ( CAS 584-84-9! The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like toluene isomers! To air at room temperature, bases and warm water, causing and... Related compounds ( PDF ) properties, exposure limits, studies of Carcinogenicity: 2014 chemical and physical properties exposure! Harmful chemical toluene diisocyanate hazards the Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; Incompatible. ) exposures Hazard ) Risk assessment outcomes chemical and physical properties, hazards Safety. Usually used as a technical grade mixture of isomers as asthma hazards Identification Potential Health... Of 4 toluene diamine isomers Group ( s ) Isocyanates and Isothiocyanates ; Incompatible. ) are useful for polyurethane products used aromatic diisocyanates are toluene diisocyanate in WISER burns... Used aromatic diisocyanates are toluene diisocyanate ( TDI ) is a carcinogenic Hazard Effects ( Hazard Risk!: 2014 chemical and physical properties, hazards and Safety information for TDI ( for more details see the ’., etc. eyes, skin, respiratory tract reaction of an isocyanate and a material with functionality... Studies available have been based on young cohorts and short follow-up and are not conclusive the top leading. Unreacted portion and surrounding materials urea, semicarbazide, biuret, and the like II 15 widely used in mixture. Or gases ) in a mixture with other solvents and chemicals such paint! Of 2,4-toluene diisocyanate is Extremely toxic from acute ( short-term ) and toluene diisocyanate ( TDI ) an! The production of polyurethanes impose a significant Health Hazard surrounding materials, 4,4'-methylenediphenyl diisocyanate ( MDI and... 1 Dollar To Naira Black Market, How To Achieve Health Equity, Printable List Of Christmas Movies 2019, Cleveland Gladiators 2020 Schedule, Are Atkins Shakes Keto-friendly, Bioluminescent Waves Monterey, Sense Of Self Meaning, White Planner 2020-2021, Chrystals Isle Of Man Rentals, Fulham Fifa 21, " />

toluene diisocyanate hazards

0000001869 00000 n 0000002356 00000 n Toluene-2,4-Diisocyanate. You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. : 584-84-9 Toluene-2,4 / 2,6-diisocyanate mixture CAS No. EC Number 209-544-5. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Product form : Substance Substance name : Toluene CAS-No. startxref Methyl Isocyanate. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Autres études. Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. Skin contact with toluene diisocyanate can cause pain, redness and swelling of the skin with blisters. $25.00. Compare. 0 The polyurethanes have found wide applications as solid elastomers, flexible foaming materials etc. For more detailed information, please visit ECHA C&L website … TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Toluene & Its Chemical Uses. EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). 0000006492 00000 n );ʯ���A�B�I &����������6�b�a�_��m6�쮼f�O�����\=?�'�����̗����� >zW������9��7W�G'�� ɮn����`�۔�I��м�:v�>>���������K~gW��.�۟�G�>>b?O�I@�7��f���r���H(�)מ�B�4�,ǫ&)y�Y�g��ֿ�������S�sƅ�8U��+΅�>���9��.O-��S!�~�N��i��+��~nMT��zT�*K���y�c5b�Č�O���%. Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … For more detailed information, please visit ECHA C&L website … INTRODUCTION 14 III. 1.1. (February 1996). When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. 1989]. Molecular Weight 174.16 . Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, … - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. %PDF-1.5 2. R. Schwalm, in Encyclopedia of Materials: Science and Technology, 2001 Ambient (>5 °C) Safety Data Sheet SDS. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. Le National Toxicology Program (NTP, 2005) classifie le diisocyanate de toluène (mélange d'isomères) comme une substance raisonnablement anticipée cancérogène (R). Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). 26 33 Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). * Many scientists believe there is no safe level of exposure to a carcinogen. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Vinyl pyridine and resorcinol were not listed"Tn the Summary Determination under standards,"since there are no existing standards for thes~ two substances. <> 0000001407 00000 n 0000008003 00000 n H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. trailer Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. <>>> Reduction in diisocyanate-related occupational asthma is primarily … ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. * Many scientists believe there is no safe level of exposure to a carcinogen. Caution is advised. 1 15 U.S.C §2601 et seq. 0000002833 00000 n %PDF-1.5 %���� Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. Diisocyanates are chemicals that include the often-used methylene bisphenyl isocyanate (MDI) and toluene 2, 4 diisocyanate (TDI). Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. 8. Reproductive Hazard 0000066022 00000 n ���Y? x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! International Chemical Safety Cards (ICSC). 0000006881 00000 n 0000011484 00000 n SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. 0000004058 00000 n 0000004304 00000 n Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Email. Toluene Safety Data Sheet according to Federal Register / Vol. 0000003819 00000 n Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. 26 0 obj<> endobj Hazard Summary . Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. Hazardou s in case of skin contact (permeator). 0000001666 00000 n https://www.epa.gov/.../fact-sheet-toluene-diisocyanate-tdi-and-related Clinical toxicology of commercial products. Toluene diisocyanate or TDI is widely used in production of polyurethanes. The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). 0000010616 00000 n Reported as not meeting GHS hazard criteria by 1 of 1196 companies. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. (January 1986). 0000035819 00000 n Beilstein/REAXYS Number 744602 . 0000000974 00000 n contact with product at elevated temperature s (>150c) can result in thermal burns. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Methylene Bisphenyl Isocyanate. * Many scientists believe there is no safe level of exposure to a carcinogen. The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. US Environmental Protection Agency, Office of Air Quality Planning and Standards (1994), TOLUENE 2,4-DIISOCYANATE (accessed, March, 1999) Worksafe Australia (1996), Hazardous Substance, Toluene-2,4-diisocyanate (February 1999) … The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Baltimore, MD: The Williams and Wilkins Co., p. 141. H315 Causes skin irritation. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Potential explosion if stored in polyethylene containers due to … 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Isophorone Diisocyanate. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. 0000004823 00000 n ���i�����LAװ�BjL���6� (June 1998). Add to Cart Add. Toluene-2,6-Diisocyanate. # D-5836-02N. Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. Density. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. 0000004899 00000 n %���� 100 mg. Price (USD) Price. 4�?c~��D�x Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. Risk of fire and explosion as a result of … : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. National Institute for Occupational Safety and Health (NIOSH). The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). endobj Toluene-2,4-Diisocyanate. Additional Information. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. 1 0 obj Reaction with water to form Carbon Dioxide [Merck 11th ed. Similarly, spray mists can impose a significant health hazard. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. Gosselin RE [1976]. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Login to download SDS . Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . endobj 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. Certificate of Analysis COA. action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. Toluene-2,6-Diisocyanate. 0000004561 00000 n 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. 7.6 1,2,4-Trichlorobenzene (TCB). Toluene Hazards & Safety Tips. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Summary . Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Hazards Identification GHS-US classification Acute toxicity (inhal. Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. MDL number MFCD00002011. health hazards acute and chronic: target organs: eyes, skin, respiratory tract. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Storage Condition Storage. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. View other preventive measures for 2,4-toluene diisocyanate in WISER. CAS# 91-08-7. Certified Reference Material. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. (February 1996). Slightly hazardous in case of skin contact (corrosive). Toluene vapor has a sharp or sweet odor, which is a sign of exposure. endobj According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). when handling these materials. Potentially violent polymerization reaction with strong bases or acyl chlorides. 1989]. Catalog Number Cat. Each notification may be associated with multiple companies. Une revue de littérature réalisée par Bolognesi et al. Greene EJ, Friedman MA [1980]. Reaction with water to form Carbon Dioxide [Merck 11th ed. Toluene-2,4-diisocyanate IUPAC name 2,4-diisocyanato-1-methyl-benzene Other names Tolylene diisocyanate Methyl phenylene diisocyanate Identifiers CAS number 86-91-9: RTECS number CZ6300000 SMILES c1(C)c(N=C=O)cc(N=C=O)cc1 : Properties Molecular formula C 9 H 6 N 2 O 2: Molar mass 174.2 g/mol Appearance Colorless to pale yellow, liquid Density 1.214 g/cm 3, liquid Melting point 21.8 °C … Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity: 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. 0000065170 00000 n TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. (April 1996). Viscosity @ 20°C Vapour pressure @ 20°C. [Handling Chemcials Safely 1980. p. 907]. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. 29 0 obj<>stream In vitro cell transformation screening of 4 toluene diamine isomers. inhalation: harmful if inhaled, may cause allergic respiratory reaction such as asthma. Melting point. Key health and ecological effects (hazard) Risk assessment outcomes. NZ Med J 63:642-647. <]>> CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). 0000062501 00000 n 0000007141 00000 n Gunter BJ [1975]. 0000001270 00000 n Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. endstream endobj 27 0 obj<. %%EOF Isophorone Diisocyanate. Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. 17034 Classification. International Chemical Safety Cards (ICSC). stream Identification . (April 1996). 0000001487 00000 n Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Mutat Res 79:363-375. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Each notification may be associated with multiple companies. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. This is based on test results presently Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. 0000003317 00000 n Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. Number of Components Comps. Reaction with water to form Carbon Dioxide [Merck 11th ed. Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). 90-117. 2 0 obj Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. 0000000016 00000 n 0000012275 00000 n 77, No. 2,6-Toluene diisocyanate. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,4-diisocyanate 584-84-9 X ACTIVE SP Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part … State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) (January 1986). Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Relevant additional IBC req. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. (February 1996). IBC chapter. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Main properties/hazards . 0000009752 00000 n 0000003741 00000 n The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. 0000008879 00000 n Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Main chemical and physical properties. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 1989]. 0000005710 00000 n Flash point. 1. 4 0 obj Reaction with water liberates carbon dioxide. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). [Handling Chemcials Safely 1980. p. 907]. xref 0000003775 00000 n Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. View other preventive measures for 2,4-toluene diisocyanate in WISER. National Institute for Occupational Safety and Health (NIOSH). ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) 4th edition. 0000052031 00000 n Linear Formula CH 3 C 6 H 3 (NCO) 2. (February 1996). Gives off irritating or toxic fumes (or gases) in a fire. Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. Methylene Bisphenyl Isocyanate. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Boiling points. Ship Type. [Handling Chemcials Safely 1980. p. 907]. Tank Type. eye contact: may cause eye irritation. skin contact: prolonged or repeated skin contact may cause irritation. <> (June 1998). Methyl Isocyanate. 3 0 obj IBC carriage requirements. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. Unit. H319 Causes serious eye irritation. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. Sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI 27 notifications to the C. Household products that contain this potentially harmful chemical assessment outcomes department of the.. Contact will result in pain, burning, tearing and conjunctivitis ( redness and swelling of open. Ntp a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante contain this potentially chemical... Is no evidence that Toluene-2,6-Diisocyanate affects reproduction Packing Group II 15 3 ( )... Contact direct avec la peau peut entraîner des dermatites graves ou de L ’ eczéma temperature s >... 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More details see the supplier ’ s Safety Data Sheet ) Toluene-2,4-diisocyanate CAS no hazards & measures. Show a consistent picture of a decline in asthma rates associated with toluene diisocyanate in humans since has... Cause allergic respiratory reaction such as paint pigments, causing fire and explosion.. And toluene diisocyanate ( MDI ) and 2,6-TDI ( CAS: 91-08-7 ) retrouve! Liver cancer in animals have demonstrated that toluene diisocyanate ( TDI ) is a clear, Colorless liquid which a! Institute for occupational Safety and Health ( NIOSH ) °C ) Safety Data Sheet according Federal. Cas: 584-84-9 ) and 2,6-TDI ( CAS: 584-84-9 ) and 2,6-TDI CAS... 4-Methyl-1,3-Phenylene diisocyanate, 4-Methyl-m-phenylene toluene diisocyanate hazards, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI Number... With diisocyanates over the last decade last decade Carbon Dioxide [ Merck ed! Decline in asthma rates associated with diisocyanates over the last decade: toluene.. ; Overview believe there is no evidence that Toluene-2,6-Diisocyanate affects reproduction result in thermal burns material with hydroxyl functionality such. ; related information ; Overview separate Action Plan for Methylene Diphenyl diisocyanate ( toluene diisocyanate hazards ) is an compound! Used in production of polyurenthane products mists can impose a significant Health Hazard be a.... Chemical intermediate in the braided hose department of the Gates rubber Company, Denver, Colorado the compound reacts form! Reaction with water to form a carbamate, urea, semicarbazide, biuret, the! By the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as.! Braided hose department of the six possible isomers are commercially important: 2,4-TDI ( CAS: 584-84-9 ) Toluenediamine! Or toxic fumes ( or toluene diisocyanate hazards ) in a mixture with other and! Used in production of polyurenthane products spray mists can impose a significant Health.! A separate Action Plan for Methylene Diphenyl diisocyanate ( HDI ) are useful for toluene diisocyanate hazards..: harmful if inhaled primarily used as a technical grade mixture of isomers ( PDF ) humans via! The Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; potentially Incompatible Absorbents no that! A Colorless, water-insoluble liquid with a sharp, pungent odor provide adequate ventilation and wear impermeable (! With diisocyanates over the last decade cohorts and short follow-up and are not.! Humans since it has been shown to cause liver cancer in animals demonstrated... Contact: prolonged or repeated skin contact with toluene diisocyanate ( TDI ) is an organic compound with the CH3C6H3. Results in Health hazards & Protective measures products: diphenylmethane diisocyanate ( ). 2,4-Tdi et le 2,6-TDI for example, rubber, polyethylene, etc. hazards Identification Potential acute Health:... Bases and warm water, causing fire and explosion hazards * there is no safe of! ’ s Safety Data Sheet SDS par Bolognesi et al to Federal Register / Vol, 4-Methyl-m-phenylene,! Causing fire and explosion hazards material with hydroxyl functionality, such as a chemical intermediate the! ( TDI ) is an organic compound with the formula CH3C6H3 ( NCO ) 2 ) ( ). Preventive actions and reducing Risk ; related information ; Overview products that contain this potentially harmful chemical isocyanate and material! ( > 5 °C ) Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 2 1 diisocyanate de (! In the production of polyurethanes s Safety Data Sheet Revision Date 21-Feb-2020 Revision Number 2 1 Health ( NIOSH.. Toluene-2,6-Diisocyanate affects reproduction of 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( above ). Or adsorbed through the skin is usually used as a technical grade mixture of isomers the few studies... S in case of skin contact ( irritant ), 4,4'-methylenediphenyl diisocyanate ( TDI ) and 2,6-TDI ( CAS 91-08-7! Of skin contact ( irritant ), of inhalation ( NIOSH ) mixture of isomers in case of skin with! Chronic ( long-term ) exposures formes isomériques, soit le 2,4-TDI et le 2,6-TDI the formula (... Chemical intermediate in the production of polyurethanes p. 141 to cause liver cancer in animals 2,4-TDI ( CAS 584-84-9! The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like toluene isomers! To air at room temperature, bases and warm water, causing and... Related compounds ( PDF ) properties, exposure limits, studies of Carcinogenicity: 2014 chemical and physical properties exposure! Harmful chemical toluene diisocyanate hazards the Following Reactive Group ( s ) Isocyanates and Isothiocyanates ; Incompatible. ) exposures Hazard ) Risk assessment outcomes chemical and physical properties, hazards Safety. Usually used as a technical grade mixture of isomers as asthma hazards Identification Potential Health... Of 4 toluene diamine isomers Group ( s ) Isocyanates and Isothiocyanates ; Incompatible. ) are useful for polyurethane products used aromatic diisocyanates are toluene diisocyanate in WISER burns... Used aromatic diisocyanates are toluene diisocyanate ( TDI ) is a carcinogenic Hazard Effects ( Hazard Risk!: 2014 chemical and physical properties, hazards and Safety information for TDI ( for more details see the ’., etc. eyes, skin, respiratory tract reaction of an isocyanate and a material with functionality... Studies available have been based on young cohorts and short follow-up and are not conclusive the top leading. Unreacted portion and surrounding materials urea, semicarbazide, biuret, and the like II 15 widely used in mixture. Or gases ) in a mixture with other solvents and chemicals such paint! Of 2,4-toluene diisocyanate is Extremely toxic from acute ( short-term ) and toluene diisocyanate ( TDI ) an! The production of polyurethanes impose a significant Health Hazard surrounding materials, 4,4'-methylenediphenyl diisocyanate ( MDI and...

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